Endocrine Abstracts

Nonadherence to levothyroxine therapy is one cause of persistent hypothyroidism. To distinguish nonadherence from malabsorption, a levothyroxine absorption test (LAT) is sometimes required. The authors report a case of a 60-year-old female patient suffering from hypothyroidism resistant to oral levothyroxine (LT4) substitution after radioiodine therapy for Graves’ disease. Despite the continuous increases of LT4, over 10 years, to a maximum of 1 mg/d...

Objective: Microalbuminuria is usually the first microvascular complication of type 1 diabetes mellitus (T1DM). We aimed to identify its frequency, time of occurrence and related risk factors.Methods: Clinical reports of 201 children followed in our institution were retrospectively analysed (diabetes duration 3.8±3.6 years, age at diagnosis 8.1±3.7 years, HbA1c value 9.0±1.7%). Statistical analysis was performed with SPSS version.21 for Wi...

Aims: To study the association of protein tyrosine phosphatase (LMW–PTP/ACP1) polymorphism with bone mineral density and metabolic parameters of bone remodelling.Methods: BMD (g/cm2) was measured by DEXA in 760 subjects: 448 normal BMD (359F/89M; 49.7±12.9 years; 30.2±5.4 kg/m2) and 312 osteoporosis (265F/47M; 63.9±10.4 years; 27.16±4.4 kg/m2). Metabolic bone remodelling parameters were analyzed: ...